Lab of Synthetic Proteins

 

Chemical Synthesis of Diubiquitin-Based Photoaffinity Probes for Selectively Profiling Ubiquitin-Binding Proteins

Angew. Chem. Int. Ed. 2017, 56, 1 – 6

 

Monomer/Oligomer Quasi-Racemic Protein Crystallography

J. Am. Chem. Soc. 2016, 138 , 14497–14502

 

Quasi-​racemic X-​ray structures of K27-​linked ubiquitin chains prepared by total chemical synthesis.

J. Am. Chem. Soc. 2016, 138, 7429-7435.

 

A synthetic molecular system capable of mirror-image genetic replication and transcription.

Nat. Chem. 2016, 8, 698-704.

 

Robust chemical synthesis of membrane proteins through a general method of removable backbone modification.

J. Am. Chem. Soc. 2016, 138, 3553-3561.

 

Total chemical synthesis of photoactivatable proteins for light-​controlled manipulation of antigen-​antibody interactions.

  Chem. Sci. 2016, 7, 1891-1895.

 

Utilization of a photoactivatable antigen system to examine B-​cell probing termination and the B-​cell receptor sorting mechanisms during B-​cell activation.

Proc. Natl. Acad. Sci. USA 2016, 113, E558-E567.

 

Diaminodiacid bridges to improve folding and tune the bioactivity of disulfide-rich peptides.

Angew. Chem. Int. Ed. 2015, 54, 14276-14281.

 

Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy.

Angew. Chem. Int. Ed. 2015, 54, 11760-11764.

 

Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo.

Nat. Commun. 2015, 6, 7220.

 

An efficient one-pot four-segment condensation method for protein chemical synthesis.

Angew. Chem. Int. Ed. 2015, 54, 5713-5717.

 

Peptide o-aminoanilides as crypto-thioesters for protein chemical synthesis.

Angew. Chem. Int. Ed. 2015, 54, 2194-2198.

 

Synthesis of and specific antibody generation for glycopeptides with arginine N-GlcNAcylation.

Angew. Chem. Int. Ed. 2014, 53, 14517-14521.

 

Expedient total synthesis of small to medium-sized membrane proteins via Fmoc chemistry.

J. Am. Chem. Soc. 2014, 136, 3695-3704.

 

Irreversible site-specific hydrazinolysis of proteins by use of sortase.

  Angew. Chem. Int. Ed. 2014, 53, 2198-2202.

 

Chemical synthesis of proteins using peptide hydrazides as thioester surrogates.

Nat. Protoc. 2013, 8, 2483-2495.

 

Diaminodiacid-based solid-phase synthesis of peptide disulfide bond mimics.

Angew. Chem. Int. Ed. 2013, 52, 9558 –9562

 

Development of new thioester equivalents for protein chemical synthesis.

Acc. Chem. Res. 2013, 46, 2475-2484.

 

Synthesis of autophagosomal marker protein LC3-II under detergent-free conditions.

Angew. Chem. Int. Ed. 2013, 52, 4858-4862.

 

Convergent chemical synthesis of proteins by ligation of peptide hydrazides.

  Angew. Chem. Int. Ed. 2012, 51, 10347-10350.

 

Genetically encoded alkenyl–pyrrolysine analogues for thiol–ene reaction mediated site-specific protein labeling.

Chem. Sci. 2012, 3, 2766-2770.

 

Fmoc synthesis of peptide thioesters without post-chain-assembly manipulation.

J. Am. Chem. Soc. 2011, 133, 11080-11083.

 

Protein chemical synthesis by ligation of peptide hydrazides.

  Angew. Chem. Int. Ed. 2011, 50, 7645-7649.